NASH Diets

Methionine and Choline Deficient (MCD) Diets
Among the different approaches for diet-induced NAFLD in rodents, MCD diets produce the most severe NASH phenotype in the shortest timeframe. MCD diets are formulated with the replacement of whole protein (such as casein) in purified diets with crystalline amino acids and the removal of both methionine and choline.

Choline Deficient (CD) Diets
Typically, CD diets used in fatty liver disease studies tend to contain higher levels of fat (45-60 kcal%) and these diets can induce steatosis, inflammation and fibrosis without the reduction in body weight typically found when feeding MCD diets, making CD diets more appealing to some researchers.

High-Fat, High-Fructose, High-Cholesterol Diets
Studies in C57BL/6 mice fed a HFD or high-fat, high-fructose (HFHFr) diet (58 Kcal% fat) with high-fructose corn syrup in water for 16 weeks showed that fructose consumption was necessary for the progression from liver fat deposition to fibrogenesis.

The following is a list of our in-stock NASH Diets:

Diet Formula

Description

Google Scholar

A06071302

L-Amino Acid Diet With 60 kcal% Fat With 0.1% Methionine and No Added Choline

References

A02082002BR

Methionine and Choline Deficient L-Amino Acid Diet

References

D09100310

Rodent Diet With 40 kcal% Fat (Mostly Palm Oil), 20 kcal% Fructose and 2% Cholesterol

References

D17010103

Rodent Diet With 40 kcal% Fat (Mostly Partially Hydrogenated Corn Oil ), 20 kcal% Fructose and 2% Cholesterol

References

D09100304

Rodent Diet With 10 kcal% Fat (Matching Sucrose to D09100310)

References

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Connect with Our Scientists

Michael A. Pellizzon, Ph.D.

Vice President, Science Director

Steven Yeung, M.S.

Director of Business Development

Sridhar Radhakrishnan, Ph.D.

Senior Scientist

Jia-Yu (Holly) Ke, Ph.D.

Senior Scientist/Asia Marketing Director

Dushyant Kshatriya, Ph.D.

Project Manager and Scientist

Shailee Jani, Ph.D.

Project Manager and Scientist

H. Emily Jang, Ph.D.

Senior Scientist

Qing Ai, Ph.D.

Project Manager and Scientist

Arashdeep Singh, Ph.D.

Project Manager and Scientist

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