Nash Diets
Methionine and Choline Deficient (MCD) Diets
Among the different approaches for diet-induced NAFLD in rodents, MCD diets produce the most severe NASH phenotype in the shortest timeframe. MCD diets are formulated with the replacement of whole protein (such as casein) in purified diets with crystalline amino acids and the removal of both methionine and choline.
Choline Deficient (CD) Diets
Typically, CD diets used in fatty liver disease studies tend to contain higher levels of fat (45-60 kcal%) and these diets can induce steatosis, inflammation and fibrosis without the reduction in body weight typically found when feeding MCD diets, making CD diets more appealing to some researchers.
High-Fat, High-Fructose, High-Cholesterol Diets
Studies in C57BL/6 mice fed a HFD or high-fat, high-fructose (HFHFr) diet (58 Kcal% fat) with high-fructose corn syrup in water for 16 weeks showed that fructose consumption was necessary for the progression from liver fat deposition to fibrogenesis.
The following is a list of our in-stock NASH Diets:
Diet Formula
Description
Google Scholar
A06071302
L-Amino Acid Diet With 60 kcal% Fat With 0.1% Methionine and No Added Choline
References
A02082002BR
Methionine and Choline Deficient L-Amino Acid Diet
References
D09100310
Rodent Diet With 40 kcal% Fat (Mostly Palm Oil), 20 kcal% Fructose and 2% Cholesterol
References
D17010103
Rodent Diet With 40 kcal% Fat (Mostly Partially Hydrogenated Corn Oil ), 20 kcal% Fructose and 2% Cholesterol
References
D09100304
Rodent Diet With 10 kcal% Fat (Matching Sucrose to D09100310)
References
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